Buy Symbicort (Budesonide / Formoterol) — Online Prescription
Symbicort is the red inhaler that pairs a steroid (budesonide) with a fast-starting, long-acting bronchodilator (formoterol) for asthma and COPD. Formoterol works within minutes, so Symbicort can do something most controller inhalers can't: in guideline-based SMART plans, it can serve as your rescue inhaler too. This guide covers dosing for adults and kids, how SMART works, side effects, generic Breyna, and how to pay $35 or less.
Medically reviewed Medically reviewed by Darcey Melnyk, Pharmacist — NPI 1740713718 · Last updated 2026-09-29
| Active ingredient | Budesonide (inhaled corticosteroid) + formoterol fumarate dihydrate (long-acting beta2-agonist) |
|---|---|
| Dosage form | HFA metered-dose inhaler: 80/4.5 mcg and 160/4.5 mcg per puff (60 or 120 puffs) |
| Administration route | Oral inhalation |
Class: Corticosteroid [EPC]
Indications: 1 INDICATIONS AND USAGE SYMBICORT is a combination product containing a corticosteroid and a long-acting beta 2 -adrenergic agonist indicated for: • Treatment of asthma in patients 6 years of age and older. ( 1.1 ) • Maintenance treatment of airflow obstruction and reducing exacerbations in patients with chronic obstructive pulmonary disease (COPD) including chronic bronchitis and/or emphysema. ( 1.2 ) Important limitations: • Not indicated for the relief of acute bronchospasm. ( 1.1 , 1.2 ) 1.1…
Contraindications: 4 CONTRAINDICATIONS The use of SYMBICORT is contraindicated in the following conditions: • Primary treatment of status asthmaticus or other acute episodes of asthma or COPD where intensive measures are required. • Hypersensitivity to any of the ingredients in SYMBICORT. • Primary treatment of status asthmaticus or acute episodes of asthma or COPD requiring intensive measures. ( 4 ) • Hypersensitivity to any of the ingredients in SYMBICORT. ( 4 )
openFDA label data — Updated 2026-09-29Symbicort is a prescription inhaler combining budesonide (an inhaled steroid) and formoterol (a long-acting bronchodilator that starts working within about 15 minutes). It's FDA-approved as 2 puffs twice daily for asthma (ages 6+) and COPD, in 80/4.5 and 160/4.5 strengths. Because it acts fast, asthma guidelines also let it be your rescue inhaler in a SMART plan, up to 12 puffs a day for adults. The generic is Breyna (budesonide/formoterol), but with AstraZeneca's $35 monthly cap, brand is often cheaper for eligible patients. Rinse and spit after each dose.
How Symbicort works
Airways start to open. In the FDA trials, meaningful bronchodilation was seen within 15 minutes.
Peak effect. The benefit lasts about 12 hours, which is why it's dosed twice daily.
Reassessment. If you're not controlled on 80/4.5, the label suggests moving to 160/4.5.
Full asthma control may take this long or longer as the steroid effect builds
Symbicort dosage: 80/4.5 vs 160/4.5, adults and kids
The first number is the budesonide (steroid) dose per puff. Formoterol is 4.5 mcg in both strengths. The standard FDA-labeled dose is 2 puffs twice daily, morning and evening about 12 hours apart.
| Who | Strength | FDA-labeled dose |
|---|---|---|
| Asthma, ages 6–11 | 80/4.5 | 2 puffs twice daily |
| Asthma, ages 12+ | 80/4.5 or 160/4.5, based on severity | 2 puffs twice daily. Maximum: 160/4.5, 2 puffs twice daily. |
| COPD (maintenance) | 160/4.5 | 2 puffs twice daily |
| SMART plan (guideline use, set by your prescriber) | Usually 80/4.5 or 160/4.5 | Daily maintenance puffs plus 1–2 puffs as needed for symptoms. Total up to 12 puffs a day (ages 12+) or 8 a day (ages 4–11). |
Symbicort as a rescue inhaler: the SMART plan
This is the feature that sets Symbicort apart from Advair and most other controllers. It's also one of the most common questions people ask: "Can I use Symbicort as a rescue inhaler?"
Controller + separate rescue
- Daily
- Symbicort, 2 puffs twice daily
- When symptoms hit
- Albuterol (the blue rescue inhaler)
- Downside
- Reliever puffs don't treat inflammation, and heavy albuterol use signals risk
One inhaler for both
- Daily
- Symbicort maintenance puffs, as prescribed
- When symptoms hit
- 1–2 extra Symbicort puffs. Each one also adds steroid.
- Guidelines
- Preferred for many people with moderate-to-severe asthma, ages 4+ (NAEPP 2020, GINA). It reduces severe flare-ups.
Using budesonide/formoterol as a reliever is recommended by US and international asthma guidelines, but it is not on the US FDA label. Don't start it on your own. Know your daily maximum: 12 puffs for ages 12+ and 8 puffs for ages 4–11. If you're near that limit, or relief isn't lasting, get medical help. SMART is an asthma strategy. For COPD, use Symbicort as prescribed and keep your usual rescue inhaler.
How to use the Symbicort inhaler
- Prime it when neededFirst use: shake well for 5 seconds and spray 2 test puffs into the air. Repeat this if it hasn't been used for more than 7 days, or if it's been dropped.
- Shake and breathe outShake for 5 seconds before each puff. Breathe out fully, away from the mouthpiece.
- Press as you breathe in slowly and deeplyStart a slow breath, press the canister once, and keep inhaling. A spacer makes this easier, especially for children.
- Hold for about 10 secondsThen breathe out slowly. Shake again and repeat for the second puff.
- Rinse and spitRinse your mouth with water after each dose and spit it out. This reduces thrush and hoarseness.
Symbicort side effects
Source: SYMBICORT FDA prescribing information, Table 2. Bars are scaled to 12%. In COPD trials, oral thrush affected 6.0% (vs. 1.8% on placebo), and lung infections other than pneumonia affected 7.9% (vs. 5.1%).
Other effects people ask about: formoterol can cause tremor, a faster heartbeat, nervousness and trouble sleeping, especially at higher reliever use. Weight gain isn't a listed side effect at inhaled doses. Coughing up phlegm usually reflects the underlying asthma or COPD, not the drug.
Pneumonia risk in COPD: watch for fever, chills and changes in mucus. Steroid effects with long-term or high-dose use: lower bone density, cataracts and glaucoma, slower growth in children, and adrenal suppression when switching from steroid pills (taper those slowly). Infections: avoid chickenpox and measles exposure if you're not immune. Heart: use caution with heart rhythm problems or high blood pressure. Never add another LABA, and stop and get help if breathing worsens right after a dose (paradoxical bronchospasm). The old boxed warning about LABA asthma deaths was removed in 2017 for steroid-plus-LABA inhalers, after four large trials involving more than 41,000 patients.
Generic Symbicort: Breyna and budesonide/formoterol
Breyna (Viatris with Kindeva) was the first FDA-approved generic of Symbicort. It was approved on March 16, 2022, launched in 2023, and uses the same 80/4.5 and 160/4.5 strengths. Unlike most generics, it isn't cheaper. This is what pharmacies pay per gram of inhaler contents:
Source: CMS NADAC, data.medicaid.gov. Symbicort's other package size was $25.46 per gram. In the December 2025 survey, Breyna ($23.18) cost pharmacies more than brand Symbicort ($22.03). NADAC is the pharmacy's cost, not your price.
At wholesale, Breyna costs about the same as brand Symbicort (it has sometimes cost more), and unbranded budesonide/formoterol about 20% less. For insured patients, AstraZeneca's $35 cap on brand is often the better deal.
Symbicort vs. Advair, Breo, Airsupra and Spiriva
| Inhaler | What's in it | How often | Can it be a reliever? | Notes |
|---|---|---|---|---|
| Symbicort / Breyna | Budesonide + formoterol (ICS/LABA) | 2 puffs twice daily | Yes, in SMART plans | Asthma 6+, COPD. Spray works with a spacer. |
| Advair / Wixela | Fluticasone + salmeterol (ICS/LABA) | Twice daily | No. Salmeterol is too slow. | Much cheaper Diskus generics. See our Advair guide. |
| Breo Ellipta | Fluticasone furoate + vilanterol (ICS/LABA) | Once daily | No | Once-a-day convenience |
| Dulera | Mometasone + formoterol (ICS/LABA) | Twice daily | Contains formoterol, but SMART evidence is mainly with budesonide/formoterol | Asthma |
| Airsupra | Albuterol + budesonide | As needed | Yes. It's a rescue inhaler. | Adults 18+. Not a daily controller. Also under AstraZeneca's $35 cap. |
| Spiriva | Tiotropium (LAMA) | Once daily | No | Often added to Symbicort in COPD ("triple therapy") |
| Breztri, Trelegy | ICS + LABA + LAMA in one inhaler | Twice daily (Breztri), once daily (Trelegy) | No | Single-inhaler triple therapy |
Symbicort vs. Advair in one line: both control asthma and COPD well, but Symbicort's fast formoterol allows the SMART one-inhaler strategy. Advair's advantage is much cheaper generics. For the steroid-only step below both, see our Flovent (fluticasone) guide. For the blue rescue inhaler, see albuterol.
Drug interactions
| Drug or class | What can happen |
|---|---|
| Strong CYP3A4 inhibitors: ritonavir, cobicistat, ketoconazole, itraconazole, clarithromycin | Raise budesonide levels, which increases steroid side effects. Use caution. |
| Beta-blockers | Can block formoterol and trigger bronchospasm |
| Non-potassium-sparing diuretics | Can add to low potassium and ECG changes |
| MAO inhibitors, tricyclic antidepressants, QT-prolonging drugs | Stronger heart effects. Use caution. |
| Other LABA products (salmeterol, arformoterol) | Don't combine |
Buy Symbicort: price, $35 cap and coupons
- Ask about the $35 cap first. Since June 2024, AstraZeneca has capped out-of-pocket cost for Symbicort at $35 a month for eligible commercially insured, uninsured and underinsured patients. It doesn't apply to Medicare or Medicaid.
- Generic isn't automatically cheaper. Breyna and unbranded budesonide/formoterol cost only modestly less than brand. With the cap, brand is often the lower out-of-pocket option. We compare both for you.
- Medicare Part D: plans usually cover a version, often the generic. Your 2026 out-of-pocket drug costs are capped at $2,100 a year.
- Prescription required. Primary care, pulmonology, allergy and telehealth prescribers can send it to us electronically, or you can transfer an existing prescription. Sites selling Symbicort "without a prescription" aren't licensed US pharmacies.
- On SMART? Refill sooner. Reliever puffs use up the inhaler faster than twice-daily dosing. Let your prescriber know so the quantity matches your plan.
Call (860) 522-9289. A pharmacist will compare the $35 brand cap with generic pricing, check your inhaler technique, and walk you through your SMART plan if your prescriber set one up.
No active shortage reported — No shortage records found for this generic name.
FDA openFDA — Updated 2026-09-29National Average Drug Acquisition Cost (NADAC): $17.264 per gram (BUDESONIDE-FORMOTEROL 160-4.5). This is the average price pharmacies pay wholesalers — not your out-of-pocket cost — published by CMS for pricing transparency.
CMS NADAC — Updated 2026-09-29Symbicort (Budesonide / Formoterol) Prices in the USA
| Dosage | Brand-name avg. price | Generic avg. price |
|---|---|---|
| 80/4.5 mcg, 120 puffs (30 days at 2 puffs twice daily) | $350–480 (Symbicort) | $220–400 (Breyna or budesonide/formoterol) |
| 160/4.5 mcg, 120 puffs (30 days at 2 puffs twice daily) | $400–520 (Symbicort) | $250–430 (Breyna or budesonide/formoterol) |
| 160/4.5 mcg, 60 puffs | $230–320 (Symbicort) | $150–260 |
Frequently asked questions
What is Symbicort used for?
Symbicort is a prescription inhaler for asthma (ages 6 and older) and for COPD maintenance (chronic bronchitis and emphysema). It combines budesonide, an inhaled steroid that reduces airway inflammation, with formoterol, a bronchodilator that starts working within minutes and lasts about 12 hours. On the FDA label it is a twice-daily controller; asthma guidelines also use it as a reliever in "SMART" plans set up by your prescriber.
Can Symbicort be used as a rescue inhaler?
Only as part of a SMART (single maintenance and reliever therapy) plan your prescriber sets up. Because formoterol starts working within minutes, US (NAEPP 2020) and international (GINA) asthma guidelines recommend budesonide/formoterol as both the daily controller and the as-needed reliever for many people with moderate-to-severe asthma. The total is capped at 12 puffs a day for ages 12 and older and 8 puffs a day for ages 4 to 11. This reliever use is guideline-recommended but not on the US FDA label, so follow the written plan you get from your prescriber — and don't use it as a reliever for COPD unless told to.
Can you take albuterol and Symbicort together?
Yes. On a standard plan, you take Symbicort twice daily as a controller and keep albuterol as your rescue inhaler. On a SMART plan, Symbicort itself is usually the reliever and albuterol may not be needed — your prescriber decides. Either way, needing extra puffs more often than usual is a sign to call your prescriber.
What is the generic for Symbicort?
Budesonide and formoterol fumarate dihydrate inhalation aerosol, in the same 80/4.5 and 160/4.5 strengths. Breyna (Viatris with Kindeva) was the first FDA-approved generic, approved in March 2022 and launched in 2023; an unbranded budesonide/formoterol generic is also sold. Generics cost pharmacies only modestly less than brand, so with the manufacturer's $35 cap, brand Symbicort is often cheaper for insured patients.
Is Breyna the same as Symbicort?
Yes — Breyna is an FDA-approved generic of Symbicort with the same two medicines (budesonide and formoterol) in the same 80/4.5 and 160/4.5 strengths and the same dosing. The inhaler looks different; use it the same way (shake, 2 puffs twice daily, rinse and spit).
What's the difference between Symbicort 80/4.5 and 160/4.5?
The first number is the budesonide (steroid) dose per puff; the formoterol dose is the same (4.5 mcg) in both. 80/4.5 is the lower steroid dose and the only strength for children 6 to 11; 160/4.5 is the higher dose for more persistent asthma in ages 12 and older and the strength used for COPD. The maximum labeled dose is 2 puffs of 160/4.5 twice daily.
How long does it take Symbicort to work?
In the FDA trials, a meaningful bronchodilator effect started within 15 minutes of a dose, peaked within 3 hours and lasted about 12 hours. Full control of asthma can take 2 weeks or longer; if you're not controlled after 1–2 weeks on 80/4.5, your prescriber may move you to 160/4.5.
Does Symbicort cause back pain?
It was reported slightly more often than with placebo in the asthma trials — 3.2% on Symbicort 80/4.5 versus 0.8% on placebo — so it's a recognized but uncommon side effect. Tell your prescriber if it's persistent. The most common side effects were colds and sore throat, headache, upper respiratory infections, sinusitis and, in COPD, oral thrush.
Is Symbicort a steroid?
It contains one. Budesonide is an inhaled corticosteroid that works locally in the airways at doses far below steroid pills. Formoterol, the other ingredient, is a bronchodilator, not a steroid. Rinsing your mouth and spitting after each dose reduces thrush and hoarseness.
Symbicort vs. Advair: what's the difference?
Both are ICS/LABA controllers. Symbicort (budesonide/formoterol) is a spray used as 2 puffs twice daily and starts working within about 15 minutes, which is why it can also be used as a reliever in SMART plans. Advair (fluticasone/salmeterol) is usually a dry-powder Diskus with 1 inhalation twice daily; salmeterol takes 30–60 minutes to act, so Advair can't be a reliever. Advair Diskus has much cheaper generics (Wixela), while Symbicort's generics are only modestly cheaper — but both brands offer $35 caps for eligible patients.
Can you take Spiriva and Symbicort together?
Yes, this is a common COPD combination: tiotropium (Spiriva), a long-acting muscarinic antagonist, added to an ICS/LABA like Symbicort is called "triple therapy." There are also single-inhaler triple products, such as Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) and Trelegy Ellipta. Your prescriber decides which combination fits.
How do I stop taking Symbicort?
Don't stop on your own. Stopping a controller suddenly can let asthma inflammation return within days to weeks and raise the risk of a serious flare-up. When asthma has been well controlled for about 3 months, your prescriber may step down gradually — for example from 160/4.5 to 80/4.5 — and monitor how you do.
Does Medicare cover Symbicort?
Most Medicare Part D plans cover budesonide/formoterol in some form, often preferring a generic. Manufacturer copay caps don't apply to Medicare, but Part D caps your total 2026 out-of-pocket drug costs at $2,100 a year. We can check which version your plan covers best.
Can children use Symbicort?
Yes — it's FDA-approved for asthma in children 6 and older at 2 puffs of 80/4.5 twice daily. Guidelines also use budesonide/formoterol SMART in children 4 and older (maximum 8 puffs a day). A spacer (valved holding chamber) helps children get the dose into their lungs. As with all inhaled steroids, pediatricians monitor growth and use the lowest effective dose.
Sources
- SYMBICORT (budesonide and formoterol fumarate dihydrate) inhalation aerosol — FDA-approved prescribing information — U.S. National Library of Medicine (DailyMed) / U.S. FDA
- Viatris announces the first FDA approval for a generic version of Symbicort, Breyna (March 16, 2022) — Viatris
- 2020 Focused Updates to the Asthma Management Guidelines (NAEPP Expert Panel Report) — National Heart, Lung, and Blood Institute (NIH)
- A Practical Guide to Implementing SMART in Asthma Management — Journal of Allergy and Clinical Immunology: In Practice
- Global Strategy for Asthma Management and Prevention (GINA Report) — Global Initiative for Asthma
- AstraZeneca caps patient out-of-pocket costs at $35 per month for its US inhaled respiratory portfolio — AstraZeneca US (2024)
- FDA Drug Safety Communication: no significant increase in risk of serious asthma outcomes with LABAs used in combination with inhaled corticosteroids — U.S. Food and Drug Administration (2017)
- NADAC (National Average Drug Acquisition Cost) — SYMBICORT, BREYNA, BUDESONIDE-FORMOTEROL — CMS
- openFDA Drug Shortages — U.S. FDA