Buy Humira (Adalimumab) — Online Prescription

Humira (adalimumab) is the injectable TNF-blocker biologic behind treatment for rheumatoid arthritis, Crohn's disease, ulcerative colitis, psoriasis, hidradenitis suppurativa and four other conditions. Here's how it works, how well it works for each condition, what the side effects really look like, the 10 FDA-approved biosimilars that now cost a fraction of the brand, and how to get it covered and filled.

Medically reviewed Medically reviewed by Sabrina Griswold, Pharm.D. — NPI 1821451063 · Last updated 2026-09-24

What Humira is and how it works

Humira is a monoclonal antibody: a lab-made protein designed to attach to one specific target in your body. Its target is tumor necrosis factor-alpha (TNF-α), a signaling protein your immune system uses to start inflammation. In rheumatoid arthritis, Crohn's disease, psoriasis and the other conditions Humira treats, TNF-α is overproduced. It keeps inflammation going when there is nothing to fight, and that inflammation damages joints, the gut lining or skin.

Two practical consequences follow from how it works:

• It's an injection, not a pill. Humira is a large protein that stomach acid would destroy, so it's injected under the skin with a pen or prefilled syringe, usually by the patient at home.
• It lowers some of your infection defenses. TNF-α is also how your body keeps infections like tuberculosis contained. That's the reason for the boxed warning and the TB test before you start.
• It's a long-term treatment, not a cure. Humira controls the disease while you take it. Stopping usually means symptoms return, so any change should be planned with your specialist.

What Humira is used for

Humira has nine FDA-approved uses. Insurers generally cover it for moderate-to-severe disease, often after a conventional treatment (such as methotrexate for rheumatoid arthritis) has been tried.

How well Humira works, by condition

Most drug pages just say Humira is "effective." The FDA label has the actual trial results. The chart below shows, for each condition, the share of patients who reached that trial's main goal on Humira compared with placebo.

Humira helps a lot in psoriasis and the arthritis conditions. In ulcerative colitis the benefit over placebo is real but modest: about 1 in 6 patients reached remission at week 8. That's why the label says to stop Humira in UC if there's no remission by week 8, and why newer drugs often come up in UC treatment decisions (see alternatives).

How long Humira takes to work

Humira is not a same-day treatment. Here's what the clinical trials show about timing. Your specialist will judge your own response against these milestones.

Humira dosage by condition

Humira dosing depends on the condition. Several conditions start with higher loading doses to bring inflammation down faster. Adult dosing from the FDA label:

Children's doses (JIA, pediatric Crohn's, UC, uveitis and adolescent HS) are based on weight: 10 mg, 20 mg or 40 mg for arthritis and uveitis, with separate loading schedules for pediatric Crohn's and UC. Your child's specialist will set these. Adults on 80 mg every other week get about the same drug exposure as on 40 mg weekly.

Humira injection: how to use the pen and store it

Most patients inject Humira at home after one training session with a nurse, prescriber or pharmacist. These are the key steps for the pen, from the FDA-approved Instructions for Use:

1. Take it out 15–30 minutes earlyLet the pen reach room temperature with both caps on. Don't warm it in a microwave or hot water. Check the expiration date, and check that the liquid is clear and colorless.
2. Choose and clean a siteUse the front of your thigh, or your lower belly at least 2 inches from your navel. Use a different spot from last time, and avoid skin that's bruised, red, hard, scarred or has psoriasis plaques. Wipe with alcohol and let it dry.
3. Squeeze and place at 90°Pinch the skin to make a raised area. Place the white needle sleeve straight against the skin (a 90-degree angle) so you can see the window.
4. Press and holdPush the pen firmly down, then press the plum activator button. You'll hear a click. Keep holding until the yellow marker fills the window and stops moving. This can take up to 15 seconds.
5. Remove and disposeLift the pen straight off. A drop of liquid is normal. Press gauze on the site (don't rub it), then put the pen in an FDA-cleared sharps container, not the household trash.

Humira side effects

The most common side effects (more than 10% of patients) are injection site reactions, upper respiratory infections, sinusitis, headache and rash. The chart shows how often each happened on Humira compared with placebo in the pooled rheumatoid arthritis trials.

A few side effects people often search for:

Boxed warning and when to call your doctor

For most adults this risk is managed with testing before starting, monitoring during treatment, and acting fast on warning signs:

Before you start: tests, vaccines, pregnancy

• TB test. A skin or blood test for latent tuberculosis is required before the first dose. If it's positive, TB treatment starts first. You'll still be watched for TB during treatment, even with a negative test.
• Hepatitis B test. Humira can reactivate hepatitis B in carriers. Carriers are monitored during treatment and for several months after stopping.
• Get vaccines up to date first. Live vaccines (such as MMR, varicella, yellow fever, and the nasal flu spray) must be avoided while on Humira. Inactivated vaccines such as the flu shot, COVID-19, pneumococcal and Shingrix are generally fine. Our pharmacists give many of these. See immunizations.
• Tell your prescriber about heart failure, multiple sclerosis or other nerve disorders, cancer history, recurring infections, or time spent in areas where fungal infections such as histoplasmosis (Ohio and Mississippi River valleys) are common.
• Pregnancy. Registry data show no pattern of birth defects (10% vs. 7.5% in a comparable unexposed group, which the registry's design can't reliably attribute to the drug). Adalimumab crosses the placenta late in pregnancy, so an exposed baby shouldn't get live vaccines, such as rotavirus, without the pediatrician's review.

Drug interactions and alcohol

Generic Humira? The 10 FDA-approved biosimilars

"Humira generic" is one of the most-searched questions about this drug. Biologics can't be copied exactly the way pills can, so instead of generics they get biosimilars: products the FDA has confirmed have no clinically meaningful differences in safety, purity or effectiveness. US biosimilars began launching in 2023, after Humira's main patents expired.

*Interchangeable status is based on FDA designations reported through mid-2025. It is often granted for specific strengths and devices only, not every presentation of a product. An interchangeable biosimilar can be substituted for Humira at the pharmacy without a new prescription where state law allows. We check the FDA Purple Book for your exact product.

The biggest savings come from unbranded biosimilars. The same product is sold without a brand name at a much lower list price. This is what US pharmacies actually pay per pen, from CMS's national drug acquisition cost survey:

At wholesale, one brand-name Humira pen costs about the same as five to seven unbranded biosimilar pens.

Humira vs. Skyrizi, Rinvoq, Enbrel and other alternatives

If Humira stops working, isn't covered, or never worked well enough, several other drug classes treat the same conditions. They block different parts of the immune system:

Skyrizi vs. Humira for psoriasis. The two work differently. Humira blocks TNF-α, which sits early in the inflammatory chain. Skyrizi blocks IL-23, which drives the specific immune cells (Th17) behind psoriasis plaques. In the head-to-head IMMvent trial, 72% of patients on risankizumab reached 90% skin clearance (PASI 90) at week 16, compared with 47% on adalimumab. Humira's advantages are its long safety record, its broad range of approved conditions (including joint disease that newer skin drugs don't all cover), and the low price of biosimilars. Many insurers still require a TNF blocker first.

Humira price, copay card and savings

Humira's list price is about $6,900 for two pens, which is one month for most adults. Very few people pay that. What you pay depends on how you're covered:

• Uninsured or underinsured? Ask about myAbbVie Assist, AbbVie's patient assistance program, which provides Humira free to people who meet income and coverage criteria. Many biosimilar makers run similar programs.
• Paying cash? An unbranded biosimilar is almost always the cheapest route. Some manufacturers have offered low cash prices through discount platforms. For example, Boehringer Ingelheim announced adalimumab-adbm at $550 per two-pack through GoodRx in 2024. Ask us for a current quote before you assume brand pricing.
• Humira coupons from random websites that promise brand Humira "without a prescription" or at pill-like prices are red flags. Genuine savings come from the manufacturer, your insurer, or a licensed pharmacy.

See our patient assistance programs page for more on copay cards and foundation grants.

How to buy Humira with a prescription

Humira is prescription-only and almost always needs prior authorization, so getting it takes a few more steps than a routine refill. Here's how it works at Arrow Pharmacy:

1. Get a prescription from your specialistThis is usually a rheumatologist, gastroenterologist or dermatologist, after your TB and hepatitis B tests. The prescriber can send it to us electronically, or you can transfer an existing prescription.
2. We check your coverageWe confirm whether your plan covers brand Humira or a specific biosimilar. We also check whether your plan requires a designated specialty pharmacy. Some do, and we'll tell you honestly if that's the case.
3. We handle the prior authorizationOur Specialty Care team gathers your chart notes from the prescriber, submits the request, and follows up with the insurer.
4. We apply the savingsThat means a manufacturer copay card if you're commercially insured, or the Medicare payment plan or patient assistance if you're not.
5. Pick up or get it delivered coldPick it up at our Hartford pharmacy, or ask about next-day delivery. We'll show you how to use the pen or syringe on your first fill.

Humira (Adalimumab) Prices in the USA

These are estimated average US retail cash prices — not insurance copays, not coupon prices, and not a quote from Arrow Pharmacy. Actual cost varies significantly by pharmacy, region, quantity, and insurance. There is no true "generic" Humira — biologics get biosimilars instead. The right-hand column shows unbranded biosimilar adalimumab (for example adalimumab-adbm or adalimumab-aaty), which pharmacies buy for roughly a fifth of the brand price (see the NADAC chart above). Branded biosimilars can carry list prices close to Humira's, so "biosimilar" alone doesn't guarantee a low price. Almost nobody pays these cash prices: commercially insured patients usually use a manufacturer copay card, and Medicare Part D caps yearly out-of-pocket drug costs at $2,100 in 2026. Call us at (860) 522-9289 for a current price.

Frequently asked questions